Yes. The wildcard character (*) can be used match any number of characters except forward-slashes (e.g., *.com will block all dot-com sites and * on its own will block all sites).

Note that * will also match no characters (e.g., foo*bar.com will block foobar.com).

If you want to match any number of characters including forward-slashes, use a double-wildcard (**).

If you want to match one or more characters, use a wildcard-plus (*+).